<rss version="2.0" xmlns:content="http://purl.org/rss/1.0/modules/content/" xmlns:dc="http://purl.org/dc/elements/1.1/"><channel><title>thembc</title><description>thembc</description><link>https://www.thembc.org.au/news-old</link><item><title>And the award goes to....our Epilepsy team!</title><description><![CDATA[Most of our epilepsy researchers attended the the International Epilepsy Conference in Instabul recently. Two of our researchers received awards: Congratulations to our PhD student, Dr. Ping Zheng, who was awarded the 2015 Harinarayan Young Neuroscientist Award by the International League Against Epilepsy. A big congratulations also to Professor Frank Vajda, Professorial Fellow and Neurologist, who received an Ambassador for Epilepsy Award.<img src="http://static.wixstatic.com/media/334104_a8165c8406704b83a65006248aef1e3e.jpg"/>]]></description><link>https://www.thembc.org.au/single-post/2015/09/14/And-the-award-goes-toour-Epilepsy-team</link><guid>https://www.thembc.org.au/single-post/2015/09/14/And-the-award-goes-toour-Epilepsy-team</guid><pubDate>Mon, 14 Sep 2015 04:54:39 +0000</pubDate><content:encoded><![CDATA[<div><div>Most of our epilepsy researchers attended the the International Epilepsy Conference in Instabul recently. </div><div>Two of our researchers received awards:</div><div>Congratulations to our PhD student, Dr. Ping Zheng, who was awarded the 2015 Harinarayan Young Neuroscientist Award by the International League Against Epilepsy. A big congratulations also to Professor Frank Vajda, Professorial Fellow and Neurologist, who received an Ambassador for Epilepsy Award.</div><img src="http://static.wixstatic.com/media/334104_1314ef6ea44a4f3f983d1fe5a0644942.jpg"/><img src="http://static.wixstatic.com/media/334104_a8165c8406704b83a65006248aef1e3e.jpg"/></div>]]></content:encoded></item><item><title>MS @MBC - kicking goals!</title><description><![CDATA[Our MS researchers have ask been very busy. The team has recently published two papers and completed 3 other major projects: Publications 1. Kalincik T, Cutter G, Spelman T, Jokubaitis V, Havrdova E, Horakova D, et al., on behalf of the MSBase Study Group (in press) Defining reliable disability outcomes in multiple sclerosis. Brain, accepted 11/07/2015 This paper evaluated disability endpoints commonly used in clinical trials, and has a potential to influence the design of future trials in MS.<img src="http://static.wixstatic.com/media/334104_f1384ac5f9a54bd59de102e71bab7c66.jpg"/>]]></description><link>https://www.thembc.org.au/single-post/2015/09/14/MS-MBC-kicking-goals</link><guid>https://www.thembc.org.au/single-post/2015/09/14/MS-MBC-kicking-goals</guid><pubDate>Mon, 14 Sep 2015 04:48:54 +0000</pubDate><content:encoded><![CDATA[<div><div>Our MS researchers have ask been very busy. The team has recently published two papers and completed 3 other major projects:</div><div>Publications</div><div>1. Kalincik T, Cutter G, Spelman T, Jokubaitis V, Havrdova</div><img src="http://static.wixstatic.com/media/334104_f1384ac5f9a54bd59de102e71bab7c66.jpg"/><div>E, Horakova D, et al., on behalf of the MSBase Study Group (in press) Defining reliable disability outcomes in multiple sclerosis. Brain, accepted 11/07/2015</div><div>This paper evaluated disability endpoints commonly used in clinical trials, and has a potential to influence the design of future trials in MS.</div><div>2. Warrender-Sparkes M, Spelman T, Izquierdo G, ... Kalincik T* and Jokubaitis V*, on behalf of the MSBase Study Group (in press) The effect of oral immunomodulatory therapy on treatment uptake and persistence in multiple sclerosis. Mult Scler, accepted 27/05/2015</div><div>Projects</div><div>Two of our student MS researchers, Tamasine Stewart and Nathaniel Lizak have recently completed their projects: Tamasine showed that the impact of relapses on accumulation of permanent neurological disability depends on the clinical presentation of relapses. Nathaniel demonstrated that progressive disability in moderately and severely advanced multiple sclerosis can be modified with disease modifying therapy, an observation with a potential impact on the clinical management of MS globally. The resulting research papers are currently under review.</div><div>Our visiting fellow, Dr Johannes Lorscheider from Switzerland has just completed a project which is the first comprehensive study to establish an objective definition of secondary progressive MS.</div></div>]]></content:encoded></item><item><title>Launch of Epilepsy Week</title><description><![CDATA["Third time's a charm" - join us for another MBC-RMH feature week! This time our epilepsy researchers step in fornt of the camera to talk about their work and the clinical trials we have active at our Centre. Stay tuned and checkout the updates on our facebook page or ask our Epileptologists a few tough question on the BRAINtranslate Forum: http://www.braintranslate.org.au/<img src="http://img.youtube.com/vi/9i4eguCKOaA/mqdefault.jpg"/>]]></description><link>https://www.thembc.org.au/single-post/2015/09/07/Launch-of-Epilepsy-Week</link><guid>https://www.thembc.org.au/single-post/2015/09/07/Launch-of-Epilepsy-Week</guid><pubDate>Mon, 07 Sep 2015 04:35:00 +0000</pubDate><content:encoded><![CDATA[<div><div>&quot;Third time's a charm&quot; - join us for another MBC-RMH feature week! This time our epilepsy researchers step in fornt of the camera to talk about their work and the clinical trials we have active at our Centre.</div><div>Stay tuned and checkout the updates on our facebook page or ask our Epileptologists a few tough question on the BRAINtranslate Forum:</div><div>http://www.braintranslate.org.au/</div><iframe src="https://www.youtube.com/embed/9i4eguCKOaA"/></div>]]></content:encoded></item><item><title>Launch of Brain Tumour Week</title><description><![CDATA[To kick start our first BRAINtranslate Brain Tumour Week, neurosurgeon Assoc. Professor Kate Drummond, highlights the 4 core aims of her clinical research team and provides insight into the clinical studies our brain tumour research group have been undertaking in 2015. Throughout the week, we will be exploring their work in more detail, so make sure to check-in each day for new features at: www.braintranslate.org.au<img src="http://img.youtube.com/vi/E7F7Gdw-dAs/mqdefault.jpg"/>]]></description><link>https://www.thembc.org.au/single-post/2015/08/04/Launch-of-Brain-Tumour-Week</link><guid>https://www.thembc.org.au/single-post/2015/08/04/Launch-of-Brain-Tumour-Week</guid><pubDate>Tue, 04 Aug 2015 01:07:08 +0000</pubDate><content:encoded><![CDATA[<div><iframe src="https://www.youtube.com/embed/E7F7Gdw-dAs"/><div>To kick start our first BRAINtranslate Brain Tumour Week, neurosurgeon Assoc. Professor Kate Drummond, highlights the 4 core aims of her clinical research team and provides insight into the clinical studies our brain tumour research group have been undertaking in 2015. Throughout the week, we will be exploring their work in more detail, so make sure to check-in each day for new features at: www.braintranslate.org.au</div></div>]]></content:encoded></item><item><title>Launch of MS Week!</title><description><![CDATA[To kick start our first BRAINtranslate Multiple Sclerosis Week, Professor Trevor Kilpatrick provides an insight into the investigations our multiple sclerosis group have been undertaking in 2015. We will be exploring their work in more detail throughout the coming week, so make sure to check-in each day for new features!<img src="http://img.youtube.com/vi/3HG-l6PH4xo/mqdefault.jpg"/>]]></description><link>https://www.thembc.org.au/single-post/2015/07/06/Launch-of-MS-Week</link><guid>https://www.thembc.org.au/single-post/2015/07/06/Launch-of-MS-Week</guid><pubDate>Mon, 06 Jul 2015 06:54:19 +0000</pubDate><content:encoded><![CDATA[<div><div>To kick start our first BRAINtranslate Multiple Sclerosis Week, Professor Trevor Kilpatrick provides an insight into the investigations our multiple sclerosis group have been undertaking in 2015. We will be exploring their work in more detail throughout the coming week, so make sure to check-in each day for new features!</div><iframe src="https://www.youtube.com/embed/3HG-l6PH4xo"/></div>]]></content:encoded></item><item><title>Epilepsy Research Update</title><description><![CDATA[In the first quarter of 2015, our Epilepsy research team produced 5 significant publications. These papers report new findings and provide key updates for studies conducted here at the Melbourne Brain Centre (MBC) and in close collaboration with our international colleagues. Make sure to tune into upcoming BRAINtranslate events if you want to learn more about these particular studies. For those eager boffins who cannot wait, just click the below links to do your own reading. A mouse model of]]></description><link>https://www.thembc.org.au/single-post/2015/05/21/Epilepsy-Research-Update</link><guid>https://www.thembc.org.au/single-post/2015/05/21/Epilepsy-Research-Update</guid><pubDate>Thu, 21 May 2015 06:05:56 +0000</pubDate><content:encoded><![CDATA[<div><div>In the first quarter of 2015, our Epilepsy research team produced 5 significant publications. These papers report new findings and provide key updates for studies conducted here at the Melbourne Brain Centre (MBC) and in close collaboration with our international colleagues.</div><div>Make sure to tune into upcoming <a href="http://www.braintranslate.org.au">BRAINtranslate</a> events if you want to learn more about these particular studies. For those eager boffins who cannot wait, just click the below links to do your own reading.</div><div><a href="http://www.ncbi.nlm.nih.gov/pubmed/25879152">A mouse model of Alzheimer’s disease displays increased susceptibility to kindling and seizure-associated death</a>. Chan J, Jones NC, Bush AI, O'Brien TJ, Kwan P. Epilepsia 2015 Apr 16. doi: 10.1111/epi.12993. [Epub ahead of print].</div><div><a href="http://www.ncbi.nlm.nih.gov/pubmed/25876511">Association of BDNF Polymorphisms with the Risk of Epilepsy: a Multicenter Study</a>. Sha'ari HM, Haerian BS, Baum L, Tan HJ, Rafia MH, Kwan P, Cherny SS, Sham PC, Gui H, Raymond AA, Lim KS, Mohamed Z. Mol Neurobiol 2015 Apr 16.</div><div><a href="http://www.ncbi.nlm.nih.gov/pubmed/25823580">Research priorities in epilepsy for the Asia-Oceanian Region.</a> Kwan P, Cabral-Lim L, D’Souza W, Jain S, Lee B-I, Liao W, Lim S-H, Otsuki T, Tan C-T, Wantanabe M; Research Task Force, Commission of Asian and Oceanian Affairs, International League Against Epilepsy. Epilepsia 2015 Mar 30. doi: 10.1111/epi.12957. [Epub ahead of print].</div><div>Point-of-care molecular diagnostic devices: an overview. Vu CLN, Chan J, Todaro M, Skafidas S, Kwan P. Pharmacogenomics. Accepted 19 February 2015.</div><div>Mindfulness-based therapy for drug-resistant epilepsy: an assessor-blinded randomized trial. Tang V, Poon WS. Kwan P. Neurology. Accepted 24 April 2015.</div></div>]]></content:encoded></item><item><title>Velacor Trial Update</title><description><![CDATA[The MBC neuroimaging and Alzheimer’s teams have been busy with a number of active clinical trials at MBC-RMH. One of the major studies has been the Velacor trial aimed to assess the safety and tolerability of 6 months of treatment with sodium selenate (30 mg per day) in patients with mild-moderate Alzheimer’s disease. The second objective of the Velacor trial was to investigate a range of cognitive, CSF and imaging biomarkers of Alzheimer’s disease progression to identify those that show most]]></description><link>https://www.thembc.org.au/single-post/2014/11/23/Velacor-Trial-Update</link><guid>https://www.thembc.org.au/single-post/2014/11/23/Velacor-Trial-Update</guid><pubDate>Sun, 23 Nov 2014 22:43:59 +0000</pubDate><content:encoded><![CDATA[<div><div>The MBC neuroimaging and Alzheimer’s teams have been busy with a number of active clinical trials at MBC-RMH. One of the major studies has been the Velacor trial aimed to assess the safety and tolerability of 6 months of treatment with sodium selenate (30 mg per day) in patients with mild-moderate Alzheimer’s disease. The second objective of the Velacor trial was to investigate a range of cognitive, CSF and imaging biomarkers of Alzheimer’s disease progression to identify those that show most promise for use as endpoints in subsequent clinical trials designed to assess treatment efficacy.</div><div>The findings of the clinical trial are currently under review, however the MRI results showed widespread changes in brain white matter over a six month period, highlighting its usefulness as a potential biomarker of disease progression and treatment response over short time periods.</div></div>]]></content:encoded></item><item><title>New Plasma Biomarkers for Alzheimer’s</title><description><![CDATA[Prof Colin Masters’ research group and collaborators have recently identified new plasma biomarkers for Alzheimer’s disease. The panel of biomarkers could distinguish individuals with Alzheimer’s disease from cognitively healthy control subjects with high sensitivity (85%) and specificity (95%). Cross-validation within the Australian Imaging Biomarker and Lifestyle (AIBL) cohort and further validation within the Alzheimer’s disease Neuroimaging Initiative (ADNI) cohort provided strong evidence]]></description><link>https://www.thembc.org.au/single-post/2014/11/13/New-Plasma-Biomarkers-for-Alzheimer%E2%80%99s</link><guid>https://www.thembc.org.au/single-post/2014/11/13/New-Plasma-Biomarkers-for-Alzheimer%E2%80%99s</guid><pubDate>Thu, 13 Nov 2014 05:30:43 +0000</pubDate><content:encoded><![CDATA[<div><div>Prof Colin Masters’ research group and collaborators have recently identified new plasma biomarkers for Alzheimer’s disease. The panel of biomarkers could distinguish individuals with Alzheimer’s disease from cognitively healthy control subjects with high sensitivity (85%) and specificity (95%). </div><div>Cross-validation within the Australian Imaging Biomarker and Lifestyle (AIBL) cohort and further validation within the Alzheimer’s disease Neuroimaging Initiative (ADNI) cohort provided strong evidence that the identified biomarkers are important for Alzheimer’s disease diagnosis.</div></div>]]></content:encoded></item><item><title>Genetic Determinants of Common Epilepsies</title><description><![CDATA[MBC researchers are one-step closer to understanding how the genes we inherit may lead to developing common forms of epilepsy. Epilepsy experts, Prof Terry O’Brien and Prof Samuel Berkovic from MBC-RMH and MBC-Austin, have genotyped 380 patients as part of a worldwide study of over 34,000 people, of whom more than 8,000 had epilepsy, which was convened by the International League Against Epilepsy (ILAE). This International consortium brought investigators together from Europe, Asia and North]]></description><link>https://www.thembc.org.au/single-post/2014/11/13/Genetic-Determinants-of-Common-Epilepsies</link><guid>https://www.thembc.org.au/single-post/2014/11/13/Genetic-Determinants-of-Common-Epilepsies</guid><pubDate>Thu, 13 Nov 2014 05:25:40 +0000</pubDate><content:encoded><![CDATA[<div><div>MBC researchers are one-step closer to understanding how the genes we inherit may lead to developing common forms of epilepsy.</div><div>Epilepsy experts, Prof Terry O’Brien and Prof Samuel Berkovic from MBC-RMH and MBC-Austin, have genotyped 380 patients as part of a worldwide study of over 34,000 people, of whom more than 8,000 had epilepsy, which was convened by the International League Against Epilepsy (ILAE). This International consortium brought investigators together from Europe, Asia and North America for the largest genome wide association study ever performed for epilepsy. The research findings show that the development of epilepsy may be determined by the combination of genes we inherit. Two genes stood out as having broad implications for epilepsy. One, a sodium channel subunit that regulates neuronal excitability (SCN1A), had previously been associated with certain familial and severe childhood epilepsies; this finding suggests it has an even broader role. Another gene for the protein protocadherin, which helps bind cells together, was also strongly associated with epilepsy.</div><div>Prof Berkovic noted that the study emphasised the complexity of the genetics of epilepsy and the importance of international collaboration to understand the many factors that contribute to epilepsy. “Findings such as these really turn our concepts on their head. It was a really exciting finding that will now be used to spearhead further research in this area.”</div><div>The paper Genetic determinants of common epilepsies: a meta-analysis of genome-wide associate studies was published in the September issue of Lancet Neurology.</div></div>]]></content:encoded></item><item><title>Intraoperative MRI Scanner Installation</title><description><![CDATA[We are now in the final stages of installation of the intraoperative MRI scanner - due to be operational July 2015. This will create a major change in how we manage our patients with brain tumours and a fantastic research tool for our team to better assist these patients through their journey.]]></description><link>https://www.thembc.org.au/single-post/2014/11/13/Intraoperative-MRI-Scanner-Installation</link><guid>https://www.thembc.org.au/single-post/2014/11/13/Intraoperative-MRI-Scanner-Installation</guid><pubDate>Thu, 13 Nov 2014 05:20:34 +0000</pubDate><content:encoded><![CDATA[<div><div>We are now in the final stages of installation of the intraoperative MRI scanner - due to be operational July 2015. </div><div>This will create a major change in how we manage our patients with brain tumours and a fantastic research tool for our team to better assist these patients through their journey.</div></div>]]></content:encoded></item><item><title>PrevANZ Study Update</title><description><![CDATA[World-first trial of vitamin D to delay development of Multiple Sclerosis (PREVANZ) poised to recruit 50th patient. The PREVANZ trial, funded by MS Research Australia, will determine whether vitamin D capsules are effective in reducing brain inflammation and attacks of early MS. Crucially, the trial examines four different daily doses of oral vitamin D. Its results are widely expected to change MS management globally, as vitamin D is almost universally affordable. It is currently run in 19]]></description><link>https://www.thembc.org.au/single-post/2014/11/13/PrevANZ-Study-Update</link><guid>https://www.thembc.org.au/single-post/2014/11/13/PrevANZ-Study-Update</guid><pubDate>Thu, 13 Nov 2014 05:11:02 +0000</pubDate><content:encoded><![CDATA[<div><div>World-first trial of vitamin D to delay development of Multiple Sclerosis (PREVANZ) poised to recruit 50th patient. The PREVANZ trial, funded by MS Research Australia, will determine whether vitamin D capsules are effective in reducing brain inflammation and attacks of early MS.</div><div>Crucially, the trial examines four different daily doses of oral vitamin D. Its results are widely expected to change MS management globally, as vitamin D is almost universally affordable. It is currently run in 19 centres in Australia and New Zealand, and scheduled to finish in early 2017. As of today, recruitment has reached 49 participants, and will ultimately recruit 240. Key MBC-RMH affiliate, Neuroscience Trials Australia, coordinates and manages the trial and MBC-RMH Deputy Dirctor Helmut Butzkueven is the Chief Investigator of the study.</div></div>]]></content:encoded></item><item><title>EXTEND-IA Trial Update</title><description><![CDATA[The EXTEND-IA trial, lead by investigators at MBC-RMH, has just completed. This unique trial investigated the potential benefits of "endovascular thrombectomy" - a minimally invasive procedure to remove the clot causing the stroke. This was compared to the standard-clot dissolving treatment "tPA" in patients carefully selected for the presence of a large vessel occlusion and evidence of salvageable brain tissue on advanced CT perfusion brain imaging. Results will be available in February 2015.]]></description><link>https://www.thembc.org.au/single-post/2014/11/13/EXTENDIA-Trial-Update</link><guid>https://www.thembc.org.au/single-post/2014/11/13/EXTENDIA-Trial-Update</guid><pubDate>Thu, 13 Nov 2014 04:52:06 +0000</pubDate><content:encoded><![CDATA[<div><div>The EXTEND-IA trial, lead by investigators at MBC-RMH, has just completed. This unique trial investigated the potential benefits of &quot;endovascular thrombectomy&quot; - a minimally invasive procedure to remove the clot causing the stroke. </div><div>This was compared to the standard-clot dissolving treatment &quot;tPA&quot; in patients carefully selected for the presence of a large vessel occlusion and evidence of salvageable brain tissue on advanced CT perfusion brain imaging. Results will be available in February 2015.</div></div>]]></content:encoded></item></channel></rss>