CLINICAL OUTCOMES RESEARCH UNIT
The CORe Unit collaborates Australia-wide, providing expertise in advanced analytics of existing or emerging clinical databases.
Rather than service provision, CORe fosters collaborative relationships. The CORe analysts are involved in conceptualisation and interpretation of research projects and work closely with principal investigators from other research teams, providing expertise in analytics as well as insight into the subject of their research.
Learn more about the CORe Unit at their website - https://core.melbourne
Associate Professor Tomas Kalincik
Associate professor Tomas Kalincik is the head of the Clinical Outcomes Research (CORe) Unit at the MBC-RMH and the co-head of the Multiple Sclerosis and Neuroimmunology Service at the Royal Melbourne Hospital. He has led a number of international collaborative research projects of comparative treatment effectiveness, management of treatment failure and individual treatment response in multiple sclerosis.
His main research interests span treatment outcomes in multiple sclerosis, individualised therapy, prognostics, epidemiology and utility of volumetric MRI in MS. Together with the CORe team, he specialises in analytics of observational data in neurology.
Dr Charles Malpas
Dr Charles Malpas is a research fellow in the Clinical Outcomes Research Unit (CORe) at the Department of Medicine, Royal Melbourne Hospital. His research at CORe covers the neurocognitive disorders and epilepsy, and involves the application of advanced statistical modelling to answer clinically relevant questions. He is particularly interested in the application of Bayesian methods to predict clinical outcomes.
He completed a postdoctoral fellowship in neuroimaging at the Murdoch Children's Research Institute (MCRI) where he was supported by an NHMRC Peter Doherty Australian Biomedical Fellowship. Clinically, he is a board-endorsed neuropsychologist (MAPS FCCN), currently working in the Comprehensive Epilepsy Program at The Alfred Hospital and in private practice. He is a chartered psychologist in the UK (CPsychol) and Associate Fellow of the British Psychological Society (AFBPsP).
Dr Sifat Sharmin
Dr Sifat Sharmin is a biostatistician with experience in the analysis of large-scale data, including longitudinal survey and administrative data and modelling of count and longitudinal time-to-event data. Her current research interest is the application and extension of complex statistical methods to understand the clinical dynamics of multiple sclerosis (MS) and compare treatment outcomes in MS patients.
She has taught biostatistics and epidemiology to graduate students at The Australian National University and The University of Melbourne.
It has been two very busy years for the Clinical Outcomes Research (CORe) Unit. Major activities include:
Established that early active immunotherapy delays conversion to secondary progressive disease stage in patients with relapsing-remitting MS (in collaboration with MSBase and University of Cambridge) - featured by 3AW Radio, Herald Sun and editorials in JAMA and JAMA Neurology
Completed the first comparison of high-efficacy therapies for MS - featured by Channel 7, Neurology Today and an editorial in The Lancet Neurology (in collaboration with MSBase)
Established coparative effectiveness of natalizumab and alemtuzumab - which are among the most potent immunotherapies for MS, and three available oral immunotherapies for relapsing-remitting MS (in collaboration with MSBase and University of Cambridge).
Developed a prototype of a predictive algorithm will help clinicians identify the MS treatment for individual patients at a given time with the best predicted individual effectiveness - featured by Neurology Today and Herald Sun (in collaboration with MSBase)
Collaborated with the Movement Disorders unit to examine utilisation of deep brain stimulation for Parkinson’s disease in Australia (in collaboration with Dr Wes Thevathasan)
Collaborated with the Department of Radiology to quantify the improvement in the accuracy of reporting new MS lesions after implementation of automated lesion-detection software (in collaboration with A/Prof Frank Gaillard)
Hosted research fellows from Cambridge UK, French MS Registry (OFSEP), University of Basel, University of Genoa, Charles University in Prague and the Danish National MS Registry
Collaborated with the Department of Psychiatry and Melbourne Neuropsychiatric Unit to develop biomarkers for use in neuropsychiatric populations (in collaboration with Dr Dhamidhu Eratne)
Worked with researchers at the Florey Institute of Neuroscience and Mental Health to develop new ways of diagnosing dementia using brain imaging (with A/ Prof Amy Brodtmann)
Involved in a clinical trial of a potential disease modifying therapy for frontotemporal dementia (with Lucy Vivash, Prof Terence O’Brien, Prof Dennis Velakoulis).
Collaborated with Department of Neurosurgery on identifying signals in serum that will enable accessible monitoring of course and prognosis of brain tumours (in collaboration with Dr Andrew Morokoff)
Collaborated with Department of Ophthalmology on investigating outcome of retinal disease in patients with severe diabetes (in collaboration with Dr Andrew Symonds)